Capacity: | 1000kg/Mon |
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Standard: | USP/Ep/Bp/Cp/IP/Jp/Who/in-House |
Storage Temp: | +25ºC |
Quality Requirement: | Strictly Quality Control |
Quality: | High Quality |
Service: | Good Service |
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Customization: |
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Description | Stavudine, a dideoxynucleoside analog of thymidine, has been introduced in the U.S.A. for the treatment of late-stage AIDS patients who are refractory to other AIDS treatments. Similar as other currently available agents for AIDS treatment such as zidovudine (AZT), didanosine, and zalcitabine, the anti-HIV activity of these 2'3'- dideoxynucleosides is ascribed to the inhibitory effect of their corresponding 5'- triphosphates against the HlVsncoded RNAdependent DNA polymerase (reverse transcriptase). While some of these drugs have rapid development of drug resistance, stavudine is active against AZT-resistant HIV strains. It has a favorable pharmacokinetic profile with more complete and less variable oral absorption than AZT and didanosine and has a bioavailability of 80-90%. |
Chemical Properties | Colourless solid |
Originator | Bristol-Myers Squibb (U.S.A.) |
Uses | Used as an antiviral. A reverse transcriptase inhibitor |
Uses | angiotensin 1 receptor antagonist |
Uses | Stavudine (Zidovudine EP Impurity A) is used as an antiviral. A reverse transcriptase inhibitor. |
Definition | ChEBI: A nucleoside analogue obtained by formal dehydration across positions 2 and 3 of thymidine. An inhibitor of HIV-1 reverse transcriptase |
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