• 396-01-0 Triamterene Is Recommended in Combination with Other Diuretics for Treating Edema Caused by Usual Reasons
  • 396-01-0 Triamterene Is Recommended in Combination with Other Diuretics for Treating Edema Caused by Usual Reasons
  • 396-01-0 Triamterene Is Recommended in Combination with Other Diuretics for Treating Edema Caused by Usual Reasons
  • 396-01-0 Triamterene Is Recommended in Combination with Other Diuretics for Treating Edema Caused by Usual Reasons
  • 396-01-0 Triamterene Is Recommended in Combination with Other Diuretics for Treating Edema Caused by Usual Reasons
  • 396-01-0 Triamterene Is Recommended in Combination with Other Diuretics for Treating Edema Caused by Usual Reasons

396-01-0 Triamterene Is Recommended in Combination with Other Diuretics for Treating Edema Caused by Usual Reasons

Capacity: 1000kg/Mon
Standard: USP/Ep/Bp/Cp/IP/Jp/Who/in-House
Storage Temp: +25ºC
Quality Requirement: Strictly Quality Control
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Basic Info.

Model NO.
396-01-0
Delivery Method
FedEx/DHL/Special Line
Delivery Time
3days
Transport Package
25kg/Drum/1000g/Bag/10g/Bag
Specification
100% raw material
Trademark
Widely
Origin
China
Production Capacity
1000kg/Mon

Product Description

396-01-0 Triamterene Is Recommended in Combination with Other Diuretics for Treating Edema Caused by Usual Reasons
 
Description Triamterene is an inhibitor of the epithelial sodium channel (ENaC; IC50 = 4.5 μM for the rat channel). In vivo, triamterene (0.5-32 mg/animal) enhances sodium secretion and decreases potassium secretion in adrenalectomized rats. Formulations containing triamterene have been used in the treatment of edema. This product is also available as an analytical reference standard .
Chemical Properties Yellow Solid
Originator Jatropur,Rohm,W. Germany,1962
Uses Triamterene is a potassium-sparing diuretic ie, it inhibits the urinary excretion of potassium
Uses Triamterene is a weak diuretic with potassium sparing properties; blocks Na+ reuptake in the kidneys.
Uses This drug is recommended in combination with other diuretics for treating edema caused by usual reasons such as circulatory insufficiency, cirrhosis of the liver, and nephrotic syndrome.
Manufacturing Process To a solution of 9 grams of 5-nitroso-2,4,6-triaminopyrimidine in 500 mi of refluxing dimethylformamide is added 9 grams of phenylacetonitrile and the refluxing is stopped. The 3 grams of anhydrous sodium methoxide is added and the mixture is refluxed for 15 minutes. The mixture is chilled and the solid is filtered and washed several times with warm water until the washings are neutral. Drying gives yellow crystals which are recrystallized with a Darco treatment from formamide-water heating the solution no hotter than 125°C.
This product is then suspended in filtered deionized water and warmed for 15 minutes. This yields the 2,4,7-triamino-6-phenylpteridine as yellow crystals with a MP of 314° to 317°C.
Therapeutic Function Diuretic
Biological Functions Triamterene (Dyrenium) results in changes in urinary electrolyte patterns that are qualitatively similar to those produced by spironolactone. The mechanism by which this agents bring about the alterations in electrolyte loss, however, is quite different. Triamterene produces this effects whether or not aldosterone or any other mineralocorticoid is present. The action of this drug is clearly unrelated to endogenous mineralocorticoid activity, and this drug is effective in adrenalectomized patients.
General Description Odorless yellow powder or crystalline solid. Melting point 316°C. Almost tasteless at first and with a slightly bitter aftertaste. Acidified solutions give a blue fluorescence. Used as a diuretic drug.
Air & Water Reactions Sensitive to light; slowly oxidized upon exposure to air. Insoluble in water.
Reactivity Profile 2,4,7-Triamino-6-phenylpteridine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Fire Hazard Flash point data for 2,4,7-Triamino-6-phenylpteridine are not available; however, 2,4,7-Triamino-6-phenylpteridine is probably combustible.
Mechanism of action Triamterene is a pyrazine derivative that inhibits reabsorption of sodium ions without increasing excretion of potassium ions. It exhibits the same approximate effect as spironolactone; however, it does not competitively bind with aldosterone receptors. Its action does not have an effect on secretion of aldosterone or its antagonists, which are a result of direct action on renal tubules.
This potassium sparing diuretic causes a moderate increase in excretion of sodium and bicarbonate ions in urine, and it raises excretion of potassium and ammonia ions. It has little effect on urine volume.
Clinical Use Triamterene can be used in the treatment of congestive heart failure, cirrhosis, and the edema caused by secondary hyperaldosteronism. It is frequently used in combination with other diuretics except spironolactone. Amiloride, but not triamterene, possesses antihypertensive effects that can add to those of the thiazides. These K+-sparing diuretics have low efficacy when used alone, since only a small amount of total Na reabsorption occurs at more distal sites of the nephron.
These compounds are used primarily in combination with other diuretics, such as the thiazides and loop diuretics, to prevent or correct hypokalemia. The availability of fixed-dose mixtures of thiazides with nonsteroidal K+-sparing compounds has proved a rational form of drug therapy. Both triamterene and amiloride are available alone or in combination with hydrochlorothiazide.
Side effects Because the actions of triamterene and amiloride are independent of plasma aldosterone levels, their prolonged administration is likely to result in hyperkalemia. Both amiloride and triamterene are contraindicated in patients with hyperkalemia.Triamterene should not be given to patients with impaired renal function. Potassium intake must be reduced, especially in outpatients.A folic acid deficiency has been reported to occur occasionally following the use of triamterene.
396-01-0 Triamterene Is Recommended in Combination with Other Diuretics for Treating Edema Caused by Usual Reasons
396-01-0 Triamterene Is Recommended in Combination with Other Diuretics for Treating Edema Caused by Usual Reasons
Hubei weideli Chemical Reagent Co., Ltd., located in Wuhan East Lake New Technology Development Zone, is a manufacturing supplier focusing on reagent products for scientific research, and its business scope includes the manufacturing of special chemical products; Disinfectant production; Sales of special chemical products; Disinfectant sales; Research and development of biological feed; Research and development of bio based materials technology; Research and development of biochemical products technology; Technical services, technical development, technical consultation, technical exchange, technology transfer and technology promotion; Sales of instruments and meters; Sales of daily glass products; Sales of technical glass products; Sales of electronic special materials; Technology import and export; Import and export of goods; Veterinary drug management; Production of disinfection products for the prevention and treatment of infectious diseases.

The company has gradually established extensive cooperation with scientific research institutions in Colleges and universities and powerful enterprises to lay a solid foundation for technological production; At the same time, we will recruit talents all over the country and keep them fresh and energetic; With more than ten years of experience and accumulation in the industry, the company further improves its market competitiveness and strengthens its support to customers.

With the help of modern ERP system, the company provides customers with accurate quotation and inventory information in time. It has a warehouse base and Laboratory of more than 1000 square meters in Jiangxia District, Wuhan. The system inventory products can be ordered on the same day, and the order number is given on the same day of delivery. The information can be queried online, followed up in real time, and customer service provides after-sales support services.

Hubei weideli Chemical Reagent Co., Ltd. is committed to scientific research.


396-01-0 Triamterene Is Recommended in Combination with Other Diuretics for Treating Edema Caused by Usual Reasons
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Registered Capital
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Plant Area
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